Evidence map›Paper›PMID 41236646›Full record

ArticlePediatric surgery international2025

Postoperative gut dysbiosis in biliary atresia patients treated by portoenterostomy or liver transplantation.

Takanori Ochi, Masahiro Takeda, Takashi Asahara, Akinobu Kurita, Yuzuru Ogata, Mitsuyoshi Suzuki, Hajime Takei, Hiroshi Nittono, Go Miyano, Hiroyuki Koga and 7 more

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Article in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Takanori OchiDepartment of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. tochi@juntendo.ac.jp.
Masahiro TakedaDepartment of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Takashi AsaharaYakult Central Institute, Yakult Honsha Co., Ltd, Kunitachi-shi, Tokyo, Japan.
Akinobu KuritaYakult Central Institute, Yakult Honsha Co., Ltd, Kunitachi-shi, Tokyo, Japan.
Yuzuru OgataYakult Central Institute, Yakult Honsha Co., Ltd, Kunitachi-shi, Tokyo, Japan.
Mitsuyoshi SuzukiDepartment of Pediatrics, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
Hajime TakeiJunshin Clinic, Bile Acid Institute, Meguro-ku, Tokyo, Japan.
Hiroshi NittonoJunshin Clinic, Bile Acid Institute, Meguro-ku, Tokyo, Japan.
Go MiyanoDepartment of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Hiroyuki KogaDepartment of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Geoffrey J LaneDepartment of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Tadaharu OkazakiDepartment of Pediatric Surgery, Juntendo University Urayasu Hospital, Urayasu-shi, Chiba, Japan.
Akio SaiuraDepartment of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
Koichi MizutaDepartment of Transplant Surgery, Saitama Children's Medical Center, Saitama-shi, Saitama, Japan.
Mureo KasaharaOrgan Transplantation Center, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan.
Atsuyuki YamatakaDepartment of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Yuichiro YamashiroProbiotics Research Laboratory, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.

Funding

Japan Society for the Promotion of Science KAKENHI grant 22K11861
6 · The paper itself

Abstract

purposeTo assess how surgery and management protocols affect gut microbiota in postoperative biliary atresia (BA) patients by comparing survivors with native livers (NL) or transplanted livers (TL) with healthy non-surgical controls (CL).

methodsSubjects were 62 post-portoenterostomy BA patients divided into 2 groups (NL and TL) and CL. All subjects were clinically stable with no dietary restrictions throughout the study period. Stool samples were compared for gut microbiota, organic acids, and fecal bile acids, while blood samples were compared for serum biochemistry and serum bile acids.

resultsStool samples from CL (n = 30) were normal while NL (n = 31) and TL (n = 31) showed gut dysbiosis with significantly decreased total bacteria and reduced predominance of obligate anaerobes, and an abundance of Clostridioides difficile, Enterobacteriaceae, and Enterococcus. The latter two were more abundant in TL than NL. Biochemistry was normal in TL. In NL, elevated AST/ALT correlated with increased Clostridioides difficile, decreased Bacteroides fragilis group, and decreased Lactobacilli. Fecal secondary bile acids were lower and serum primary and secondary bile acids were higher in NL and TL compared with CL.

conclusionGut dysbiosis was present in both NL and TL. Pathogenic florae were more abundant in TL despite TL biochemistry being normal.

Indexed as

Biliary AtresiaDysbiosisGastrointestinal MicrobiomeLiver TransplantationPortoenterostomy, HepaticPostoperative ComplicationsBile Acids and SaltsCase-Control StudiesFecesFemaleHumansInfantMaleBile Acids and SaltsBile acidsBiliary atresiaGut microbiotaLiver transplantationNative liver

Identifiers

PMID41236646

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.