ArticleAnnals of hematology2025
Early allogeneic stem cell transplantation after melphalan-induced aplasia leads to long-term survival in patients with primary refractory AML.
Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The prognosis of patients with AML, who fail to achieve complete remission after induction therapy (= primary refractory disease) has been dismal for many years. Allo-HSCT is the only curative approach and standard of care for eligible patients in this group. The need for inducing a remission before transplantation in primary refractory patients has not been finally clarified. The objective of this retrospective single-center evaluation is to analyze the outcomes of primary refractory patients who underwent immediate allogeneic HSCT after chemotherapy induced aplasia in the context of the conditioning regimen in a real-life setting. We started a program of immediate transplantation policy for eligible patients with refractory AML after induction chemotherapy in our center in 2010. All patients with a diagnosis of primary refractory AML who underwent their first allogeneic hematopoietic stem cell transplantation in active disease between 03/2010 and 07/2023 at the department of Hematology at Klinikum Nuremberg, Germany, were included and analyzed. 50 patients were included in this analysis. Mean time from start of induction treatment to transplantation was 3 months (range 1.4-7.8 months). Melphalan (100-140 mg/m
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