Evidence map›Paper›PMID 41236499›Full record

ArticleJournal of the American Chemical Society2025

Asymmetric Synthesis of Quaternary Hydantoins via a Palladium-Catalyzed Aza-Heck Cyclization.

Ellie A Meck, Humair M Omer, Montana J Edwards, Temidayo D Idowu, Mariah L Murray, Katerina M Korch, Donald A Watson

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ellie A MeckDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0003-1133-3233
Humair M OmerDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Montana J EdwardsDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Temidayo D IdowuDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0009-0004-9049-2025
Mariah L MurrayDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0002-3785-0207
Katerina M KorchDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Donald A WatsonDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0003-4864-297X

Funding

This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI SCHMITZ, KARL ROBERT · 2014 to 2024
$26.8M
Watson Phase I COBRE Research CoreP20GM156674 · NIGMS · UNIVERSITY OF DELAWARE · PI Donald Allen Watson · 2025 to 2026
$7.5M
Pilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI PATEL, SANDEEP · 2014 to 2018
$5.8M
Chemistry-Biology Interface Predoctoral Training Grant 2024-2029T32GM133395 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine Leimkuhler Grimes · 2019 to 2026
$3.7M
Cross Couplings of Amine and Alcohol Derivatives to Give Enantioenriched ProductsR01GM111820 · NIGMS · UNIVERSITY OF DELAWARE · PI WATSON, MARY P · 2014 to 2018
$1.6M
Transition Metal Catalyzed Methods for Preparing Nitroalkanes and Alkyl AminesR01GM102358 · NIGMS · UNIVERSITY OF DELAWARE · PI WATSON, DONALD ALLEN · 2014 to 2018
$1.6M
Novel Reactions of Electrophilic Nitrogen for Preparing Bioactive MoleculesR01GM145617 · NIGMS · UNIVERSITY OF DELAWARE · PI WATSON, DONALD ALLEN · 2022 to 2025
$1.4M
High Sensitivity NMR Spectrometer with CryoprobeS10OD025185 · OD · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2019 to 2019
$930k
Q-Exactive Orbitrap LC-MC/MS SystemS10OD016267 · OD · UNIVERSITY OF DELAWARE · PI JOHNSTON, MURRAY V · 2013 to 2013
$573k
High Performance Digital NMR SpectrometerS10RR026962 · NCRR · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2010 to 2010
$500k
NCRR NIH HHS S10 RR026962NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P20 GM156674NIGMS NIH HHS P30 GM110758NIGMS NIH HHS R01 GM102358NIGMS NIH HHS R01 GM111820NIGMS NIH HHS R01 GM145617NIGMS NIH HHS T32 GM133395NIH HHS S10 OD016267NIH HHS S10 OD025185
6 · The paper itself

Abstract

An asymmetric, palladium-catalyzed aza-Heck cyclization to prepare enantioenriched 5,5-disubstituted hydantoins (quaternary hydantoins), which are medicinally important compounds but are classically challenging to prepare, is reported. The required substrates can be prepared readily from α,β-unsaturated amides in a single operation, and aza-Heck cyclization provides a wide range of topologically complex, highly substituted, pharmaceutically relevant hydantoins. The capacity of this method to impact the synthesis of drug substances is demonstrated by the first asymmetric synthesis of the anticonvulsant (

Identifiers

PMID41236499
PMCPMC12703750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.