ArticleBrain and behavior2025
Cognitive Behavioral Therapy for Reproductive Concerns and Psychological Status in Reproductive-aged Breast Cancer Survivors: A Pretest-Posttest Intervention Study.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
introductionReproductive-aged breast cancer (BC) survivors face significant distress related to fertility concerns and psychological health, yet interventions specifically targeting these issues are lacking.
objectiveThis study aimed to evaluate the effectiveness of a cognitive-behavioral therapy (CBT) intervention on fertility concerns and psychological status in this population.
designA quasi-experimental pretest-posttest study.
methodsThis study was conducted with 30 premenopausal BC survivors who desired future pregnancy. Participants were recruited via convenience sampling from a hospital and a clinic in Sari, Northern Iran. They underwent a six-week, group-based, face-to-face CBT program delivered by a reproductive health specialist. Fertility concerns were measured using the reproductive concerns after cancer (RCAC) scale, and psychological status was assessed with the depression, anxiety, and stress Scales (DASS-21) at baseline and immediately post-intervention. Data were analyzed using paired t-tests and the Bonferroni correction using in SPSS 24.
resultsThe CBT intervention resulted in statistically significant reductions in scores across five of the six RCAC subscales: concerns about fertility potential, partner disclosure, child's health, personal health, and becoming pregnant (p < 0.001). Concerns regarding acceptance of possible infertility did not show a significant change (p = 0.628). Furthermore, participants demonstrated significant decreases in symptoms of depression (p < 0.001), anxiety (p < 0.001), and stress (p = 0.031) on the DASS-21.
conclusionA structured CBT intervention is an effective short-term strategy for alleviating specific fertility-related concerns and improving the psychological well-being of premenopausal BC survivors. The findings support the integration of psychological support, particularly CBT, into survivorship care programs to address the complex reproductive and mental health challenges faced by this group. Further research with a control group and long-term follow-up is recommended to confirm these findings.
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