ReviewDermatology practical & conceptual2025
Tretinoin for Photodamaged Facial Skin: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Review in Dermatology practical & conceptual, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Different Retinoid Micellar Formulations on Wound Healing: Efficacy and Collagen Structure.Pharmaceutics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRandomized controlled trials have suggested that tretinoin, a topical retinoid, can improve wrinkling in photodamaged skin; however, its overall effectiveness remains subject of debate.
objectivesThis study evaluated the efficacy and safety of tretinoin in treating facial wrinkles induced by photodamage.
methodWe systematically searched the PubMed, EMBASE, and Cochrane CENTRAL databases from their inception to 16 January 2024 to identify randomized controlled trials comparing topical tretinoin with vehicle treatments. Data were synthesized using a random effects model, and sensitivity analyses were performed to evaluate the robustness of the results in the presence of potential bias.
resultsThis study identified eight trials (1,361 patients; median age range 29-76 years; average follow-up duration, 16 weeks to 2 years) that met the inclusion criteria. Compared with the vehicle, topical tretinoin significantly improved clinical signs of facial photodamage. Improvements were observed in both fine wrinkles (mean difference [MD]: 0.412; 95% confidence interval [CI]: 0.233- 0.590; P<0.001) and coarse wrinkles (MD: 0.245; 95% CI: 0.119-0.370; P<0.001). Sensitivity analyses confirmed the robustness of these findings.
conclusionTopical tretinoin is a safe and effective treatment for fine and coarse facial wrinkles resulting from photodamage.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.