ArticleDermatology practical & conceptual2025
Dermoscopy as a Predictor of Photodynamic Therapy Outcomes in Actinic Keratoses and Bowen's Disease: Prospective Study in Solid Organ Transplant Patients.
Article in Dermatology practical & conceptual, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionSolid organ transplant recipients (SOTRs) have a significantly higher risk of developing cutaneous squamous cell carcinoma. Identifying predictive markers for response to non-surgical treatments such as photodynamic therapy (PDT) may help optimize management strategies.
objectivesTo evaluate the association between dermatoscopic features in actinic keratoses (AK) and Bowen's disease (BD) and response to PDT in SOTRs.
methodsA prospective observational study was conducted, including 35 SOTRs with clinically and histologically confirmed AK or BD treated with methyl aminolevulinate-PDT. Thirteen dermatoscopic features were analyzed to assess their correlation with treatment response.
resultsResponse rates were 62.5% for AK and 89.47% for BD. Among the dermatoscopic features evaluated, white structureless areas in AK and rosettes in BD were significantly associated with resistance to PDT.
conclusionsDermoscopy may serve as a valuable tool to predict PDT response in SOTRs with AK and BD, potentially improving patient selection and treatment outcomes.
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