ArticleClinical and translational science2025
The Dorsal Forearm as a Novel Target for Intramuscular Injections: Clinical Pharmacokinetic Results With Naloxone.
Article in Clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- The Dorsal Forearm as a Novel Target for Intramuscular Injections: Clinical Pharmacokinetic Results With Naloxone.Clinical and translational science · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dorsal forearm represents a potentially viable location for a convenient wearable device for the administration of intramuscular (IM) injections, but this site has not previously been formally targeted for this purpose. The objectives of this study were to administer naloxone via IM injection into the dorsal forearm, characterize the pharmacokinetic (PK) profile of this injection site, and compare it to that of a standard IM injection. The study was an outpatient, open-label, single period, single treatment, single dose proof of concept (PoC) trial in 12 healthy subjects. After screening, participants provided a time zero (pre-dose) blood sample and then were administered 2 mg naloxone HCl as an IM injection in the extensor digitorum communis (EDC) muscle of the dorsal forearm. Serial blood (plasma) samples were obtained from the contralateral arm prior to dosing and serially thereafter for PK analysis. Naloxone concentrations were determined using a validated assay. PK parameters were generated from the naloxone concentration-time data. The means and ranges of the PK profile of naloxone administered IM in the forearm were: C
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