Evidence map›Paper›PMID 41236137›Full record

ArticleClinical and translational science2025

Pharmacokinetic-Pharmacodynamic Model of Paclitaxel-Induced Peripheral Neuropathy.

Yuchen Sun, Manjunath P Pai, N Lynn Henry, Daniel L Hertz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuchen SunDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA.ORCID 0000-0001-9936-0476
Manjunath P PaiDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA.ORCID 0000-0001-7119-5034
N Lynn HenryDepartment of Internal Medicine, Division of Hematology/Oncology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0002-4771-5930
Daniel L HertzDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA.ORCID 0000-0003-0501-1035

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Michigan Institute for Clinical and Health Research (MCHR)KL2TR000434 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$1.7M
NCATS NIH HHS KL2 TR000434NCATS NIH HHS UL1 TR000433
6 · The paper itself

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common neurological toxicity of paclitaxel treatment in patients with cancer that can cause irreversible reductions in function and quality of life. CIPN risk is higher in patients with greater systemic paclitaxel exposure, including the maximum concentration at the end of infusion (C

Indexed as

Antineoplastic Agents, PhytogenicBreast NeoplasmsModels, BiologicalPaclitaxelPeripheral Nervous System DiseasesAdultAgedComputer SimulationDose-Response Relationship, DrugFemaleHumansMiddle AgedQuality of LifeAntineoplastic Agents, PhytogenicPaclitaxelpaclitaxelperipheral neuropathypersonalized dosingpharmacodynamic modelingpharmacokinetics

Identifiers

PMID41236137
PMCPMC12616876

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.