Impact of therapeutic pharmaceuticals on water bodies: diagnosis, ecological threat, and removal strategies.

Among emerging contaminants, pharmaceutical compounds have garnered significant scientific attention due to their presence in the environment and potential adverse effects on aquatic ecosystems and human health. The detection of pharmaceutical compounds, their ecological threat, and water quality was evaluated at six points along the Cauca River, Colombia's second most important river. The detected compounds included diclofenac, ibuprofen, naproxen, and paracetamol, with the latter presenting maximum concentrations of up to 4.20μg/L. Domestic wastewater discharges impacted the river's water quality, increasing the frequency and concentration of pharmaceutical contaminants. Ibuprofen and paracetamol were identified as high-risk compounds for aquatic biota, with Hazard Quotient (HQ) values between 190 and 250 in areas near urban wastewater discharges. This finding also indicated a high ecological risk due to the mixture of these pharmaceuticals. No single removal technology proved completely effective, highlighting the need for complementary treatments to conventional systems to ensure safe discharge into water bodies. Moreover, given the presence of these compounds in surface waters, drinking water treatment systems must be adapted to minimize health risks in distributed water. Finally, the study underscores the need for regulatory measures and continuous wastewater monitoring to protect both aquatic ecosystems and public health.