Evidence map›Paper›PMID 41235903›Full record

ArticleThe European journal of neuroscience2025

The Human Claustrum Activates Across Multiple Cognitive Control Tasks.

Celine H L Huang, Brent W Stewart, Chun Yin Liu, Phivos Phylactou, Brian N Mathur, David A Seminowicz

Abstract read
In one paragraph

Article in The European journal of neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Multiscale characterization of the human claustrum from histology to MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Cell-type-specific sustained value representations in the claustrum.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Celine H L HuangDepartment of Neuroscience, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.ORCID 0009-0000-8773-7029
Brent W StewartDepartment of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, Maryland, USA.
Chun Yin LiuDepartment of Medical Biophysics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.
Phivos PhylactouSchool of Physical Therapy, University of Western Ontario, London, Ontario, Canada.
Brian N MathurDepartment of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
David A SeminowiczDepartment of Medical Biophysics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.

Funding

Natural Sciences and Engineering Research Council of CanadaWolfe-Western Fellowship At-Large for Outstanding Newly Recruited Research Scholars Endowment Fund
6 · The paper itself

Abstract

Cognitive control, the ability to manage information during purposeful actions, is crucial for everyday functioning and can become impaired in a variety of neuropsychiatric disorders. The claustrum, a subcortical brain structure with widespread cortical connections, is proposed to activate with cognitive load to support cortical network demands across cognitive domains. With this model in mind, we examined the claustrum signal within a dataset (n = 55) that includes functional MRI (fMRI) of healthy participants engaged in four well-established cognitive control tasks: the Stroop task, AX-continuous performance task (AX-CPT), cued task-switching and Sternberg working memory task. Bilateral claustrum activation was observed during certain conditions and trial phases of all four tasks, particularly during times of increased cognitive demand, and coinciding with task-positive cortical network activations. These findings demonstrate claustrum activation across multiple cognitive control tasks and potentially pave the way for new insights into how cognitive processes are compromised in neuropsychiatric disorders.

Indexed as

ClaustrumCognitionExecutive FunctionAdultBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMemory, Short-TermPsychomotor PerformanceStroop TestYoung Adultattentionclaustrumcognitive controlcortical networksfunctional neuroimagingworking memory

Identifiers

PMID41235903
PMCPMC12617337

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.