ArticleInvestigative ophthalmology & visual science2025
Applicability of Electroretinography Measurements in Congenital PAX6-Related Aniridia.
Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Association of Topical Therapy and Surgical Management with Corneal Parameters in Congenital PAX6-Related Classical Aniridia: a Cross-Sectional Study.Ophthalmology and therapy · 2026Article
- Applications of Photopic Negative Response: A Narrative Review.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Congenital PAX6-aniridia is associated with ocular developmental abnormalities, including photoreceptor specification. We focused on characterizing retinal function by electroretinography (ERG) measurements and evaluated the usefulness of a handheld electrophysiology tool. Methods: Patients underwent a comprehensive ophthalmological examination including best corrected visual acuity (BCVA) and full-field ERG measurements using the RETeval system with sensor strip skin electrodes. In addition to International Society for Clinical Electrophysiology of Vision (ISCEV) standards, photopic negative responses (PhNRs) were recorded. Results: Forty-one eyes of 21 patients (10 and 11 male patients, age = 25.3 ± 16.9 years, range = 9-60 years) from 16 families were included. BCVA ranged from light perception to 0.3 logMAR (mean = 1.02 ± 0.54) and exhibited greater impairment in older patients. Despite considerable variability in ERG amplitudes, no statistically significant difference was observed in ERG amplitudes between patients and controls (n = 18). However, implicit times (ITs) were significantly delayed (P < 0.001). Although PhNR response amplitudes and ITs were not significantly different from controls, W-ratio was considerably lower in patients (W = 0.89 ± 0.1) than in controls (W = 1.09 ± 0.05), indicating reduced signal transmission through the different layers of the retina. We observed an effect of glaucoma status causing even lower W-ratios (W = 0.94 ± 0.13 without confirmed glaucoma; and W = 0.88 ± 0.11 with treated glaucoma). ERG recordings were well-tolerated. Conclusions: This is the largest ERG study conducted in congenital aniridia. Results show that both photoreceptor-related functions and postreceptoral signal transmission are affected in PAX6-related aniridia, suggesting retinal changes beyond the central macula. RETeval can serve as a useful instrument for the evaluation and surveillance of retinal function in aniridia, underscoring the potential risk of glaucoma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.