Evidence map›Paper›PMID 41235724›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism.

Kieran Joyce, Aert F Scheper, Aung Myat Phyo, Roisin O' Flaherty, Richard Drake, Aiden Devitt, Martina Marchetti-Deschmann, Radka Saldova, Abhay Pandit

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kieran JoyceCÚRAM, Research Ireland Centre for Medical Devices, Biomedical Sciences Building, University of Galway, Galway, H91 W2TY, Ireland.ORCID https://orcid.org/0000-0002-7752-9784
Aert F ScheperCÚRAM, Research Ireland Centre for Medical Devices, Biomedical Sciences Building, University of Galway, Galway, H91 W2TY, Ireland.
Aung Myat PhyoCÚRAM, Research Ireland Centre for Medical Devices, Biomedical Sciences Building, University of Galway, Galway, H91 W2TY, Ireland.
Roisin O' FlahertyDepartment of Chemistry, Maynooth University, Maynooth, W23 F2K8, Ireland.
Richard DrakeDepartment of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, South Carolina, 29425, USA.
Aiden DevittSchool of Medicine, University of Galway, Galway, H91 TK33, Ireland.
Martina Marchetti-DeschmannInstitute of Chemical Technologies and Analytics, TU Wien, Vienna, 1060, Austria.
Radka SaldovaCÚRAM, Research Ireland Centre for Medical Devices, Biomedical Sciences Building, University of Galway, Galway, H91 W2TY, Ireland.
Abhay PanditCÚRAM, Research Ireland Centre for Medical Devices, Biomedical Sciences Building, University of Galway, Galway, H91 W2TY, Ireland.ORCID https://orcid.org/0000-0002-6292-4933

Funding

Centre for Microscopy and ImagingEuropean Commission's Horizon 2020 funding programmeiPSpine project 825iPSpine project 925Irish Government's Programme for ResearchNational Development PlanPREMUROSA H2020-MSCA-ITN 2019-860462Research Ireland and the European Regional Development Fund 13/RC/2073_P2University of Galway, Galway, Ireland
6 · The paper itself

Abstract

Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP), a significant global health burden. While glycosylation plays a key role in cellular signaling and inflammation, its role in IVD degeneration remains poorly understood. This study characterizes glycan alterations in human healthy and degenerated IVDs using glycomic (UPLC-MS, MALDI-IMS) and proteomic (LC-MS) analyses, combined with functional studies. These results identify hypersialylation, especially α-2,6-linked sialic acid, as a prominent feature of degenerated IVDs. In vitro inhibition of sialylation (3Fax-peracetyl Neu5Ac) in nucleus pulposus cells demonstrates reduced oxidative stress and inflammatory signaling, indicating a functional role for hypersialylation in IVD pathology. Targeting glycosylation pathways, notably sialylation, emerges as a promising therapeutic strategy for IVD degeneration.

Indexed as

InflammationIntervertebral Disc DegenerationAdultFemaleGlycosylationHumansIntervertebral DiscMaleMiddle AgedNucleus PulposusOxidative StressPolysaccharidesProteomicsPolysaccharidesglycosylationinflammationintervertebral discsialylation

Identifiers

PMID41235724
PMCPMC12866799

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.