ArticleDevelopmental medicine and child neurology2026
Academic and cerebrovascular outcomes after neurodevelopmental screening in sickle cell disease: A longitudinal cohort study.
Article in Developmental medicine and child neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed.
- Academic and cerebrovascular outcomes after neurodevelopmental screening in sickle cell disease: A longitudinal cohort study.Developmental medicine and child neurology · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
aimTo assess the predictive validity of neurodevelopmental screening in toddlers and preschool children with sickle cell disease (SCD) using the Ages and Stages Questionnaire (ASQ). We expected screening in preschool children to predict academic problems in elementary school and future stroke risk.
methodUsing a longitudinal cohort design, academic problems (e.g. grade retention, failing a subject) and increases in stroke risk (e.g. abnormal transcranial Doppler exam) were assessed for a 6-year period after neurodevelopmental screening in 2-year-olds ('toddlers') and 4-year-olds ('preschool children') using medical record review, which included annual information from parents about school functioning. Biopsychosocial variables were examined as alternate predictors.
resultsIn total, 30% of toddlers and 34% of preschool children had positive screenings. For toddlers (n = 111), positive screenings on the ASQ predicted academic problems (p = 0.009), but not increased stroke risk (p = 0.938). For preschool children (n = 110), positive screenings predicted academic problems (p < 0.001) and increased stroke risk (p = 0.018). The ASQ independently predicted academic outcomes across cohorts; baseline biomedical factors were unique predictors of stroke across cohorts.
interpretationScreening with the ASQ allows for risk stratification for neurodevelopmental outcomes in SCD. Screening in preschool children is important because of changing risk factors with age.
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