Evidence map›Paper›PMID 41235655›Full record

ArticleAIDS (London, England)2025

Resistance to broadly neutralizing antibodies in perinatally infected infants from a Clade C HIV cohort in Mozambique.

Lesley R de Armas, Marina Tuyishime, J Shawn Justement, Shalini Jha, Vinh Dinh, Benjamin Bone, Rajendra Pahwa, Paula Vaz, Maria Grazia Lain, Guido Ferrari and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lesley R de ArmasDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL.
Marina TuyishimeDepartment of Surgery, Duke University, Durham, NC, USA.
J Shawn JustementLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Shalini JhaDepartment of Surgery, Duke University, Durham, NC, USA.
Vinh DinhDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL.
Benjamin BoneDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL.
Rajendra PahwaDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL.
Paula VazFundação Ariel Glaser contra o SIDA Pediátrico, Maputo, Mozambique.
Maria Grazia LainFundação Ariel Glaser contra o SIDA Pediátrico, Maputo, Mozambique.
Guido FerrariDepartment of Surgery, Duke University, Durham, NC, USA.
Tae-Wook ChunLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Savita PahwaDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL.

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney CollaboratoryUM1AI164566 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Ann M Chahroudi, Deborah Persaud · 2021 to 2026
$35.5M
Immunity and HIV persistence in perinatal HIV infectionR01AI127347 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PAHWA, SAVITA · 2016 to 2020
$3.3M
NIAID NIH HHS P30 AI064518NIAID NIH HHS R01 AI127347NIAID NIH HHS UM1 AI164566
6 · The paper itself

Abstract

Antiretroviral therapy (ART) effectively controls HIV replication but adherence in infants and children remains a challenge. This study analyzed broadly neutralizing antibody (bNAb) resistance in viral isolates from perinatally infected infants from Mozambique. We found high intra-individual bNAb resistance heterogeneity, unrelated to viral burden, and evidence for early or preexisting resistance. These findings underscore the importance of individualized resistance screening and reinforce the need for accessible, adherence-supportive ART strategies in pediatric HIV.

Indexed as

Antibodies, NeutralizingBroadly Neutralizing AntibodiesDrug Resistance, ViralHIV-1HIV AntibodiesHIV InfectionsCohort StudiesFemaleHumansInfantInfant, NewbornMaleMozambiqueViral LoadAntibodies, NeutralizingBroadly Neutralizing AntibodiesHIV Antibodies

Identifiers

PMID41235655
PMCPMC12904168

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.