Evidence map›Paper›PMID 41235390›Full record

ArticleCurrent research in pharmacology and drug discovery2025

BCS II/IV antibiotics blended with SPEEK nanofibrous mat as an alternative for recurrent wound care: An

Himabindu Padinjarathil, Carmelo Drago, Sandro Dattilo, Libera Vitiello, Kaarthick Raaja Venkatachalam, Thirugnasambandam G Manivasagam, Prasanna Ramani

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Article in Current research in pharmacology and drug discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Himabindu PadinjarathilDhanvanthri Laboratory, Department of Chemistry, Amrita School of Physical Sciences, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India.
Carmelo DragoInstitute of Biomolecular Chemistry, CNR, via Paolo Gaifami 18, 95126, Catania, Italy.
Sandro DattiloInstitute for Polymer, Composite and Biomaterials, CNR, via Paolo Gaifami 18, 95126, Catania, Italy.
Libera VitielloDepartment of Chemical and Materials Engineering and Industrial Production, University of Naples Federico II, Piazzale Vincenzo Tecchio 80, 80125, Naples, Italy.
Kaarthick Raaja VenkatachalamDhanvanthri Laboratory, Department of Chemistry, Amrita School of Physical Sciences, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India.
Thirugnasambandam G ManivasagamDepartment of Chemical Engineering and Materials Science, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India.
Prasanna RamaniDhanvanthri Laboratory, Department of Chemistry, Amrita School of Physical Sciences, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The repeated dressing changes, especially for infected wounds and those with high exudate, and applying drugs daily, are huge demands in wound management. Sustained and regulated medication release of BCS II/IV antibiotics improves chronic wound therapy. The poor solubility and absorption of BCS-class medicines makes it challenging at target site. This work seeks to build 3D nano scaffolds for administering ciprofloxacin, a BCS II/IV class medication, using biocompatible sulphonated polyether ether ketone mat produced by electrospinning, which is flexible. We demonstrated a reliable method to prevent burst drug release and maintain it for three weeks, with good biocompatibility, minimal cytotoxicity, and excellent tensile strength characterizing sulphonated polyether ether ketone. Nanofibers improve medication interaction and delivery due to their high specific surface area ratio.

Indexed as

BCS II/IV class drugsCiprofloxacinControlled drug releaseDrug release kineticsIn vitro and in vivo modelsNanofibrous mat

Identifiers

PMID41235390
PMCPMC12607090

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.