Evidence map›Paper›PMID 41235357›Full record

ArticleOncology letters2026

Sensitive cell-free DNA assay for accurate detection of RAS and BRAF mutations in liquid biopsies of patients with metastatic colorectal cancer: Final results of the multicentric ColoBEAM study.

Alexandre Harlé, Céline Gavoille, Olivier Bouché, Meher Ben Abdelghani, Jérome Plaza, Dominique Spaeth, Axelle Boudrant, François Ghiringhelli, Anne-Laure Villing, Christophe Borg and 6 more

Registry-linked trialAbstract read
In one paragraph

Article in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02751177 (Multicenter Prospective Study Comparing KRAS, NRAS and BRAF Mutation Testing Using OncoBEAM Technique in Plasma vs Conventional Techniques in Formalin Fixed Paraffin Embedded Tissues), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02751177 nacompletednot on this map

Multicenter Prospective Study Comparing KRAS, NRAS and BRAF Mutation Testing Using OncoBEAM Technique in Plasma vs Conventional Techniques in Formalin Fixed Paraffin Embedded Tissues

TypeinterventionalSponsorInstitut de Cancérologie de LorraineRan2016 to 2017Enrolled236ConditionsColorectal Cancer MetastaticArmsKRAS, NRAS et BRAF mutation analysis from circulating plasma DNA
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alexandre HarléDépartement de Biopathologie, Institut de Cancérologie de Lorraine, CNRS UMR 7039 CRAN, Université de Lorraine, 54519 Vandoeuvre-Lès-Nancy, France.
Céline GavoilleDepartment of Medical Oncology, Institut de Cancérologie de Lorraine, 54519 Vandœuvre-lès-Nancy, France.
Olivier BouchéDepartment of Digestive Oncology, CHU Reims, Université de Reims Champagne Ardenne, 51000 Reims, France.
Meher Ben AbdelghaniDepartment of Medical Oncology, Centre Paul Strauss, 67000 Strasbourg, France.
Jérome PlazaDepartment of Medical Oncology, Hôpitaux Privés de Metz, 57000 Metz, France.
Dominique SpaethDepartment of Medical Oncology, Polyclinique de Gentilly, 54000 Nancy, France.
Axelle BoudrantDepartment of Oncology, William Morey Hospital, 71000 Chalon-sur-Saône, France.
François GhiringhelliDepartment of Medical Oncology, Centre Georges-Francois Leclerc, 21000 Dijon, France.
Anne-Laure VillingDepartment of Oncology, Auxerre Hospital, Auxerre 88000, France.
Christophe BorgDepartment of Medical Oncology, Centre Hospitalier Universitaire Jean Minjoz, 25000 Besançon, France.
Marie RouyerInstitut de Cancérologie de Lorraine, Département de Biopathologie, 54519 Vandœuvre-lès-Nancy, France.
Marie HussonInstitut de Cancérologie de Lorraine, Département de Biopathologie, 54519 Vandœuvre-lès-Nancy, France.
Pauline GilsonDépartement de Biopathologie, Institut de Cancérologie de Lorraine, CNRS UMR 7039 CRAN, Université de Lorraine, 54519 Vandoeuvre-Lès-Nancy, France.
Julia SalleronBiostatistics Unit, Institut de Cancérologie de Lorraine, 54519 Vandœuvre-lès-Nancy, France.
Aurélien LambertDepartment of Medical Oncology, Institut de Cancérologie de Lorraine, 54519 Vandœuvre-lès-Nancy, France.
Jean-Louis MerlinDépartement de Biopathologie, Institut de Cancérologie de Lorraine, CNRS UMR 7039 CRAN, Université de Lorraine, 54519 Vandoeuvre-Lès-Nancy, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The multicentric prospective ColoBEAM study (NCT02751177) aimed to assess the feasibility of using liquid biopsy for the detection of

Indexed as

BRAFKRASliquid biopsymetastatic colorectal cancerNRAS

Identifiers

PMID41235357
PMCPMC12606561

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.