Evaluating Compliance and Impact of the Sepsis Six Bundle in the Emergency Department: A Retrospective Cohort Study.

Background and objectives Sepsis resuscitation bundles are the subject of numerous quality improvement initiatives that have recently been implemented globally. These educational initiatives have been shown to be associated with improvements in clinical outcomes. The aim of this study was to evaluate the compliance and impact of the Sepsis Six bundle in the emergency department (ED). Methodology A cohort study was conducted among 660 patients who had been diagnosed with sepsis in the ED of a tertiary care center. Results The mean age of study participants was 44.8±11.7 years. Of the total, 37% of the patients were female and 63% were male. Among the study participants, 286 (43.3%) patients had the presence of shock; 220 (33.3%) had the presence of sepsis at the time of admission, and 440 (66.7%) had the presence of sepsis after 24 hours of admission. The primary site of infection in the majority of study participants was the lung, followed by the brain, haematological origin, and the kidney. A mortality rate of 32% was noted. Conclusion Targeted quality improvement measures, staff training, and streamlined ED workflows are warranted to enhance adherence to the Sepsis Six bundle and ultimately improve survival rates in septic patients.