ReviewCureus2025
Evaluating the Beneficial Effect of Empagliflozin in Reducing Hospitalisation for Heart Failure in Patients With Type 2 Diabetes Mellitus: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cardiovascular complications, with heart failure (HF) remaining a major cause of hospitalisation and mortality. Empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, has demonstrated consistent cardioprotective effects in patients with type 2 diabetes mellitus (T2DM). Evidence shows that treatment with empagliflozin reduces the risk of hospitalisation for HF, with benefits that appear to extend beyond glucose lowering. These effects are thought to be mediated through mechanisms such as improved cardiac loading conditions, enhanced natriuresis, and optimised myocardial metabolism. Overall, empagliflozin represents an effective therapeutic option for reducing cardiovascular morbidity and hospital admissions in individuals with T2DM who are at risk for HF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.