SynthesisFrontiers in public health2025
Passive smoking exposure and incidence and disease outcomes of inflammatory bowel disease: a systematic review and meta-analysis.
Synthesis in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Risk factors for chronic pouchitis in patients with ulcerative colitis following ileal pouch-anal anastomosis: a meta-analysis.Frontiers in medicine · 2026Pooled it
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Inflammatory bowel disease includes a range of chronic gastrointestinal disorders, most commonly Crohn's Disease (CD) and ulcerative colitis (UC). This systematic review and meta-analysis aims to evaluate the effect of passive smoking on incidence and disease outcomes of CD and UC. Methods: This review was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Meta-analysis was performed according to the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines. The literature was systematically searched from inception until May 2025 to identify relevant studies from a range of databases including MEDLINE, CINAHL, Embase, Scopus and Cochrane Library. Results: The initial search yielded 151 articles, with 32 studies deemed relevant for inclusion. Significant associations with passive smoking exposure were seen in 8 out of 20 studies for increased risk of CD and 3 out of 17 studies for UC. Meta-analysis found that passive smoking during childhood (OR 1.19, 95% CI 1.05-1.35) and exposure to smoking during pregnancy (OR 1.27, 95% CI 1.03-1.55) was associated with increase in odds of CD; however neither exposure was associated with an increased odds of UC. Associations with CD were also not confirmed in sensitivity analysis of higher-quality studies. Passive smoking was associated with disease complications including pouch-itis and backwash-ileitis in UC; while exposure to smoking during pregnancy was associated with hospitalisation and colorectal neoplasia in CD. There is inconclusive evidence surrounding the effects of passive smoking on need for medications and surgery. Discussion: Findings of this review highlight the importance of educating on harms of passive smoking. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251035510.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.