Trial reportDrug design, development and therapy2025
Effect of Oliceridine Combined with Sufentanil on Patient-Controlled Intravenous Analgesia in Elderly Patients After Laparoscopic Radical Resection of Rectal Cancer: A Prospective Randomized Controlled Study.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy and safety of oliceridine versus sufentanil in perioperative anesthesia and analgesia: a systematic review and meta-analysis with trial sequential analysis.European journal of clinical pharmacology · 2026Pooled it
- Oliceridine versus sufentanil: a systematic review and meta-analysis of postoperative nausea and vomiting.BMC anesthesiology · 2026Pooled it
- Oliceridine used for patient-controlled analgesia on postoperative quality of recovery in patients undergoing laparoscopic gynecological tumour resection: a randomized clinical trial.Annals of medicine · 2026Trial
- Comparison of Oliceridine and Hydromorphone for Postoperative Analgesia in Adults Undergoing Lower Limb Fracture Surgery: A Randomized Controlled Non-Inferiority Trial.Drug design, development and therapy · 2026Trial
- The Satisfactory Analgesia and Minimal Emesis of Elderly Patients After Thoracoscopic Lung Surgery: Oliceridine versus Sufentanil in a Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
- Effect of Oliceridine on the Acute Postoperative Pain Management After Elective Cesarean Delivery: A Randomized Non-Inferiority Trial.Drug design, development and therapy · 2026Trial
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- Article
- Article
- Oliceridine versus Sufentanil for Postoperative Intravenous Analgesia in Patients Undergoing Abdominal Surgery in the AICU: A Double-Blind Non-Inferiority Trial.Drug design, development and therapy · 2026Article
- Effects of oliceridine-based patient-controlled intravenous administration on postoperative pain and hemodynamic stability in elderly patients undergoing laparoscopic surgery for colorectal cancer.American journal of cancer research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Currently, there is no report on the efficacy evaluation of oliceridine in patient - controlled intravenous analgesia (PCIA) for elderly patients after surgery. This study aims to investigate the analgesic effect of oliceridine combined with sufentanil under the PCIA treatment mode. Methods: A total of 112 patients were randomly assigned to the sufentanil group (Group S), the oliceridine group (Group O), and the oliceridine + sufentanil group (Group Z). Patients in Group S received 2.0 µg/kg sufentanil; those in Group O received 0.35 mg/kg oliceridine; and patients in Group Z received 1.0 µg/kg sufentanil + 0.35 mg/kg oliceridine. The visual analogue scale (VAS) for pain at rest and during activity within 48 hours after surgery were used as the primary outcome indicators. The secondary observation indicators include the Athens Insomnia Scale (AIS) score for postoperative sleep quality, the number of times the analgesia pump is pressed within 48 hours after surgery, the situation of rescue analgesia, and the occurrence of adverse events. Results: Among the 112 patients analyzed, the combination of oliceridine and sufentanil significantly reduced the VAS scores for pain at rest and during activity within 48 hours after surgery (p < 0.01), and had the lowest incidence rates of postoperative nausea and vomiting (PONV) and respiratory depression (p < 0.05). Meanwhile, this combination regimen significantly decreased the AIS scores (P < 0.001), the times of analgesia pump pressing (p < 0.01), the times of rescue analgesia (p < 0.05), and the rescue analgesia rate (P < 0.001). Conclusion: In the pain management after laparoscopic radical resection of rectal cancer in elderly patients, oliceridine combined with sufentanil provides the best analgesic effect and has the lowest incidence of adverse reactions associated with opioids.
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