ArticleInternational journal of pediatrics2025
Utility of Clinical, Laboratory, and Radiological Parameters for Detecting Hypovolemia in Edematous Children With Steroid-Sensitive Nephrotic Syndrome-A Prospective Observational Study.
Article in International journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A prospective observational study was conducted in 90 edematous children with steroid-sensitive nephrotic syndrome (SSNS) to determine the prevalence of hypovolemia and also to study the role of surrogate markers like severe edema, high hematocrit, inferior vena cava collapsibility index (IVCCI) ≥ 50%, blood urea/creatinine ≥ 100 : 1, and serum albumin < 1.5 gm/dL in identifying hypovolemia. The diagnostic test for hypovolemia was a combination of FeNa < 0.5 and urinary potassium (UK) index ≥ 0.6. One-third of children with SSNS had hypovolemia, of which 50% were symptomatic. High hematocrit was the most sensitive surrogate marker of hypovolemia (80%), followed by serum albumin < 1.5 g/dL (56.6%), IVCCI ≥ 50% (43%), severe edema (36.7%), and blood urea/creatinine ≥ 100 : 1 (33.3%). The specificity for detecting hypovolemia was maximum for IVCCI ≥ 50% (91.6%), followed by blood urea/creatinine ≥ 100 : 1 (90%), serum albumin < 1.5 g/dL (85%), severe edema (81.7%), and hemoconcentration (21.6%).
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