Evidence map›Paper›PMID 41235096›Full record

ReviewCurrent genomics2025

Role of Long Noncoding RNA Dio3os in Glycolipid Metabolism.

Xinchen Wang, Shiyun Zeng, Yuting Liu, Yulan Shi, Fenghua Qu, Li Li, Qirui Zhang, Ding Yuan, Chengfu Yuan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinchen WangThird-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, China.
Shiyun ZengThird-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, China.
Yuting LiuThird-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, China.
Yulan ShiThird-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, China.
Fenghua QuThird-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, China.
Li LiCollege of Basic Medical Science, China Three Gorges University, Yichang 443002, China.
Qirui ZhangThird-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, China.
Ding YuanThird-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, China.
Chengfu YuanThird-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Recent investigations have underscored the importance of long non-coding RNAs (lncRNAs), which exhibit more specific expression in tissues and cells than mRNA and are involved in gene regulation during development, pathology, and other processes through various mechanisms. Despite the predominant focus on the role of lncRNA Dio3os in cancer research, there has been relatively limited exploration of its potential involvement in glycolipid metabolism. Therefore, this study aims to consolidate existing knowledge on the function of Dio3os in glycolipid metabolism and calls for a broader investigation into its physiological roles. Methods: This review synthesizes available literature to detail the gene characteristics of lncRNA Dio3os and its expression patterns. It also compiles recent insights and mechanisms pertaining to Dio3os's involvement in glycolipid metabolism, particularly its participation in the ceRNA regulatory network. Results: Recent studies demonstrate that lncRNA Dio3os regulates glycolysis in cancer cells and impacts obesity, potentially serving as an indicator for diabetic peripheral neuropathy. Furthermore, its diminished expression has been noted in atherosclerotic plaques. Conclusion: lncRNA Dio3os exerts a significant regulatory influence on glycolipid metabolism, with variations in its expression levels potentially affecting disease presentations. Further investigations are warranted to elucidate the precise relationship between lncRNA Dio3os and its associated pathologies.

Indexed as

ceRNA networkdiabetic peripheral neuropathyDio3osgenerational obesityGlycolipid metabolismlncRNA

Identifiers

PMID41235096
PMCPMC12606660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.