ArticleMediterranean journal of hematology and infectious diseases2025
Evolving Disease Spectrum and Characteristics of People with HIV in Eastern China: A 12-Year Study.
Article in Mediterranean journal of hematology and infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Real-world efficacy and safety of PD-1 inhibitors in patients living with HIV and cancer: a retrospective cohort study.Frontiers in oncology · 2026Article
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5 authors.
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Abstract
Background: Acquired immunodeficiency syndrome (AIDS) caused by human immunodeficiency virus (HIV) remains a serious public health problem. Opportunistic infections and malignancies are the more frequent causes of hospitalization. We investigated hospitalized people with HIV (PWH) over the past 12 years to determine the types and changing trends of the disease presentation in a large tertiary academic centre in Eastern China. Methods: We evaluated a total of 2,140 hospitalized PWH from January 2010 to December 2021. Demographic, clinical, and laboratory data, as well as opportunistic infections, malignancies, and in-hospital outcomes, were collected and analyzed. Results: Over time, the incidence of opportunistic infections has declined. Conversely, the incidence of malignancies has increased, with non-AIDS-defining cancers (NADCs) occurring more frequently than ADCs. Notably, in 2020-2021, the incidence of NADCs surpassed that of opportunistic infections, marking a novel shift in the disease spectrum. The overall in-hospital mortality rate was 8.1%, and in-hospital mortality gradually decreased over time. Opportunistic infections, malignancies, and CD4 Conclusion: Our study provided a comprehensive description of the disease characteristics of PWH in eastern China over the past 12 years. The disease spectrum of PWH has undergone tremendous changes over time, highlighting the necessity of early HIV diagnosis and broader access to optimal treatment and management strategies.
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