ArticleMediterranean journal of hematology and infectious diseases2025
Post-Load Plasma Glucose Increase (PG-gap) as a Risk Factor for Developing Dysglycemia in Patients with Transfusion-Dependent β-Thalassemia (β-TDT): Retrospective Analysis over 8 Years.
Article in Mediterranean journal of hematology and infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Concordance Rate of Fasting Plasma Glucose (PG) and 2-hour PG post Oral Glucose Tolerance Test (OGTT) in Patients with New Diagnosis of Thalassemia-Related Diabetes Mellitus (Th-RDM): Implications for Clinical Practice.Mediterranean journal of hematology and infectious diseases · 2026Article
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Abstract
Background: Abnormal glucose homeostasis in transfusion-dependent β-thalassemia (β-TDT) patients requires early detection and intervention. However, current diagnostic criteria for patients with a normal oral glucose tolerance test (OGTT) may fail to detect a significant proportion of high-risk individuals. Objectives: The main objective of this study was to evaluate in β-TDT patients with normal fasting plasma glucose (FPG) and glucose tolerance (NGT), the plasma glucose (PG) incremental rise gap during OGTT, defined as the difference between 2h-PG and FPG (PG-gap), as an early predictor index associated with future risk of developing dysglycemia and thalassemia-related diabetes mellitus (Th-RDM). Research design patients and methods: 58 β-TDT patients, recruited from three Thalassemia centers (Iran, Italy, and Greece), were selected for the study. The patients underwent a routine OGTT, and the PG-gap between 2-h PG and FPG (2-h PG - FPG) was calculated. The patients were categorized into three groups based on the results: "Low post-load" when the gap was < 20 Results: Follow-up was available for 6 years in all 58 patients, including 8-year data in 45 patients. The incidence of dysglycemia, namely, isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), IFG plus IGT, isolated high 1-h PG (>155 mg/dL), after OGTT, and thalassemia-related diabetes mellitus (Th-RDM), was significantly lower in Groups A and B (27/45 patients) compared to Group C (18/45 patients) (χ Conclusions: The findings suggest that a high post-load plasma glucose gap (≥ 75
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