Evidence map›Paper›PMID 41234974›Full record

ArticleCureus2025

Advancements in Fibrinogen Replacement for Major Bleeding: Insights From Case Series.

David S Shapiro, Daniel Katz, John J Kowalczyk, Grace Lim, Roman Dudaryk, Tjorvi Perry

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David S ShapiroDepartment of Surgery, University of Connecticut School of Medicine, Farmington, USA.
Daniel KatzDepartment of Anesthesiology, The Mount Sinai Hospital, New York, USA.
John J KowalczykDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Grace LimDepartment of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, USA.
Roman DudarykDepartment of Anesthesiology, University of Miami, Coral Gables, USA.
Tjorvi PerryDepartment of Anesthesiology, University of Minnesota, Minneapolis, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case series explores the role of fibrinogen replacement in managing major bleeding across cardiac, obstetric, and trauma contexts. Acquired fibrinogen deficiency (AFD) frequently complicates hemostasis during major bleeding by impairing clot stability. We examine three cases where fibrinogen is repleted with fibrinogen concentrate (FC) or pathogen-reduced cryoprecipitate, rather than cryoprecipitate, to manage perioperative bleeding in cardiac surgery, postpartum hemorrhage, and trauma-induced coagulopathy. These cases underscore the need for timely fibrinogen replacement in critical bleeding situations, highlighting potential clinical benefits of rapid repletion of fibrinogen, and, in addition, we review ideal treatment options based upon viscoelastic testing (VET).

Indexed as

anesthesiologybleedingbleeding and blood productscardiac surgeryfibrinogenobstetrical hemorrhageresuscitationtraumatic hemorrhage

Identifiers

PMID41234974
PMCPMC12611339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.