Evidence map›Paper›PMID 41234938›Full record

ArticleFrontiers in neurology2025

The combination of atrial fibrillation and small vessel disease score worsen spontaneous intracerebral hemorrhage outcomes.

Yuki Hamada, Takeo Sato, Hideki Matsuoka, Yuka Tsuchimochi, Kaishi Kukihara, Yutaro Kawabata, Kana Iwamoto, Go Takaguchi, Yujiro Higuchi, Hiroshi Takashima

Abstract read
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In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yuki HamadaDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Takeo SatoDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Hideki MatsuokaDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Yuka TsuchimochiDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Kaishi KukiharaDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Yutaro KawabataDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Kana IwamotoDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Go TakaguchiDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Yujiro HiguchiDepartment of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Hiroshi TakashimaDepartment of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to examine whether the presence of atrial fibrillation (AF), severity as judged by total small vessel disease (SVD) score, or a combination of these is associated with prognosis and hematoma volume of spontaneous intracerebral hemorrhage (sICH). Methods: This retrospective analysis investigated 608 patients who were admitted within 7 days of ICH onset between July 2012 and November 2023. The primary outcome was prognosis at 3 months after onset according to the modified Rankin Scale (mRS) score. Associations of AF, SVD and a combination of these with outcomes and hematoma volume were examined using univariate analyses, logistic regression analysis, and multiple regression analysis. Results: A total of 608 consecutive patients with sICH were screened, and 330 patients were finally included in the analysis after applying the inclusion and exclusion criteria. Among the 330 patients analyzed, 145 (43.9%) experienced poor outcomes (mRS score 4-6). The presence of AF was independently associated with poor outcome (adjusted OR 4.93, 95% CI 1.72-16.1; Conclusion: The presence of AF was associated with poor 3-month outcomes and increased estimated hematoma volume in sICH patients, whereas total SVD score alone was not. The effects of AF and SVD together appear to contribute synergistically to worsened prognosis and increased hematoma volume in sICH patients.

Indexed as

atrial fibrillationbrain-cardiac interactionfunctional outcomeintracerebral hemorrhagesmall vessel disease

Identifiers

PMID41234938
PMCPMC12605216

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