ArticleTranslational cancer research2025
Study of non-surgical therapeutic patterns and prognosis in elderly patients with stage II non-small-cell lung cancer: an investigational study based on the SEER database.
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: While surgery remains the standard of care for stage II non-small-cell lung cancer (NSCLC) for most patients, numerous older patients are non-surgical candidates because of either frailty or comorbidities. We aim to assess the comparative effectiveness of chemoradiotherapy (CRT) compared to radiotherapy (RT) for older patients with stage II NSCLC using data from the Surveillance, Epidemiology, and End Results (SEER) database and propensity score matching (PSM) methods. Surgery remains the approved standard of care for stage II NSCLC. But for older populations, those aged 65 years or older, they often may not undergo surgery for a variety of reasons. Methods: We selected 2,646 patients ≥65 years of age with stage II NSCLC from the SEER database. Patients were divided into CRT and RT groups. PSM was completed with demographic and clinical variables, including age, sex, tumor stage, histology, and primary site. We used Kaplan-Meier (KM) survival analysis and multivariable Cox proportional hazards models to analyze overall survival (OS) and cancer-specific survival (CSS). Results: Before PSM, the 3- and 5-year OS rates in the CRT group were 29.3% and 16.8% Conclusions: In summary, CRT was associated with improved OS and CSS in non-surgical stage II NSCLC patients aged 65 years or older.
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