ArticleTranslational cancer research2025
Predictive factors for clinical outcome of palliative ventriculoperitoneal shunt in the treatment of leptomeningeal metastasis.
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Leptomeningeal metastasis (LM) is associated with poor prognosis and affects the quality of life (QOL) of end-stage cancer patients, particularly when accompanied by hydrocephalus. Ventriculoperitoneal shunt (VPS) is recognized as an effective therapy for patients with this condition, but previous studies have focused on clinical effects. This study aimed to explore the predictors of clinical outcome in patients with LM who underwent VPS. Methods: Thirty-seven patients who underwent VPS after being diagnosed with LM at Huashan Hospital, Fudan University, from June 2018 to June 2024 were enrolled. Clinical outcomes were evaluated using the Karnofsky performance status (KPS) at baseline and one week postoperatively. A good outcome was defined as a ≥30% improvement in KPS, while a poor outcome was <30%. Patients were accordingly grouped into good and poor outcome categories. Potential predictive factors, including the type of primary malignancy, presence of hydrocephalus, location and extent of LM, preoperative lumbar puncture pressure (measured in mmH Results: Two factors showed significant differences between the good- and poor-outcome groups: the hydrocephalus (P=0.008) and lumbar puncture pressure (P=0.003). Multivariate analyses revealed that lumbar puncture pressure (P=0.006) was the only significant predictor of clinical outcome. Conclusions: The lumbar puncture pressure was the only independent predictive factor of the clinical outcomes of VPS for the treatment of patients with LM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.