ArticleTranslational cancer research2025
NSD2 mediates NF-κB and matrix metalloproteinases to drive hepatocellular carcinoma malignant progression.
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality globally, with limited therapeutic options available for advanced stages. Elucidating the molecular drivers of hepatocarcinogenesis holds promise for the development of targeted therapeutic strategies. Nuclear receptor-binding SET domain-containing protein 2 (NSD2), a histone lysine methyltransferase, is now recognized as a critical modulator of tumor progression. The aim of this study was to investigate the role of NSD2 in HCC. Methods: Messenger ribonucleic acid (mRNA) and protein levels were determined in 20 HCC patients, publicly available databases and HCC cell lines. The Results: The findings revealed that NSD2 expression was markedly elevated in both HCC patients' samples and cell lines. Elevated NSD2 expression was closely linked to poor prognosis in HCC patients. Furthermore, our experimental findings highlighted the critical role of NSD2 in enhancing the proliferation, migration, and invasion of HCC cells, while simultaneously inhibiting apoptosis both Conclusions: In summary, NSD2 acts as a tumorigenic factor in the progression of HCC by activating the NF-κB and MMPs signalling pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.