Evidence map›Paper›PMID 41234774›Full record

ArticleiScience2025

CUT&Tag overcomes biases of ChIP and establishes chromatin patterns for repetitive genomic loci.

Brandon J Park, Shan Hua, Karli D Casler, Eric Cefaloni, Michael C Ayers, Rahiim F Lake, Kristin E Murphy, Paula M Vertino, Mitchell R O'Connell, Patrick J Murphy

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Genomic Profiling of Chromatin State Using CUT&Tag.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brandon J ParkUniversity of Rochester Medical Center, Wilmot Cancer Center, Department of Biomedical Genetics, Rochester, NY, USA.
Shan HuaUniversity of Rochester Medical Center, Wilmot Cancer Center, Department of Biomedical Genetics, Rochester, NY, USA.
Karli D CaslerUniversity of Rochester Medical Center, Wilmot Cancer Center, Department of Biomedical Genetics, Rochester, NY, USA.
Eric CefaloniUniversity of Rochester Medical Center, Wilmot Cancer Center, Department of Biomedical Genetics, Rochester, NY, USA.
Michael C AyersUniversity of Rochester Medical Center, Wilmot Cancer Center, Department of Biomedical Genetics, Rochester, NY, USA.
Rahiim F LakeUniversity of Rochester Medical Center, The Department of Biochemistry & Biophysics and Center for RNA Biology, Rochester, NY, USA.
Kristin E MurphyUniversity of Rochester Medical Center, Wilmot Cancer Center, Department of Biomedical Genetics, Rochester, NY, USA.
Paula M VertinoUniversity of Rochester Medical Center, Wilmot Cancer Center, Department of Biomedical Genetics, Rochester, NY, USA.
Mitchell R O'ConnellUniversity of Rochester Medical Center, The Department of Biochemistry & Biophysics and Center for RNA Biology, Rochester, NY, USA.
Patrick J MurphyUniversity of Rochester Medical Center, Wilmot Cancer Center, Department of Biomedical Genetics, Rochester, NY, USA.

Funding

University of Rochester Wilmot Cancer Institute Support GrantP30CA272302 · NCI · UNIVERSITY OF ROCHESTER · PI JONATHAN W FRIEDBERG · 2025 to 2026
$6.4M
Programmable RNA-targeting CRISPR-Cas tools to study RNA biologyR35GM133462 · NIGMS · UNIVERSITY OF ROCHESTER · PI Mitchell O'Connell · 2019 to 2026
$3.6M
Function of Chromatin Features in Cellular ProgrammingR35GM137833 · NIGMS · UNIVERSITY OF ROCHESTER · PI Patrick J. Murphy · 2020 to 2026
$2.8M
NCI NIH HHS P30 CA272302NIGMS NIH HHS R35 GM133462NIGMS NIH HHS R35 GM137833
6 · The paper itself

Abstract

New

Indexed as

genomic analysisMethodology in biological sciencessequence analysis

Identifiers

PMID41234774
PMCPMC12605858

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.