Evidence map›Paper›PMID 41234726›Full record

ArticleFrontiers in oncology2025

Clinical outcome of 115 patients with synchronous bilateral Wilms' tumor: largest cohort of single-center experience.

Hosam Y Asfour, Wael Zekri, M Hany Hussein, Naglaa Elkinaai, Sarah Sobhy, Mahmoud M Helmy, Azza Nasr, Amal Refaat, Rana Gamal, Alaa Younes and 2 more

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Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Hosam Y AsfourDepartment of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.
Wael ZekriDepartment of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.
M Hany HusseinDepartment of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.
Naglaa ElkinaaiDepartment of Pathology, National Cancer Institute, Cairo University, Cairo, Egypt.
Sarah SobhyDepartment of Pathology, Children Cancer Hospital Egypt (CCHE), Cairo, Egypt.
Mahmoud M HelmyDepartment of Pathology, Children Cancer Hospital Egypt (CCHE), Cairo, Egypt.
Azza NasrDepartment of Radiation Oncology, National Cancer Institute, Cairo University, Children Cancer Hospital Egypt (CCHE), Cairo, Egypt.
Amal RefaatDepartment of Radiodiagnosis Oncology, National Cancer Institute, Cairo University, Children Cancer Hospital Egypt (CCHE), Cairo, Egypt.
Rana GamalSchool of Global Public Health, The American University in Cairo (AUC), Cairo, Egypt.
Alaa YounesDepartment of Surgical Oncology, National Cancer Institute, Cairo University, Children Cancer Hospital Egypt (CCHE), Cairo, Egypt.
Moatasem El-AyadiDepartment of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.
Sahar A KhalilDepartment of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Bilateral Wilms' tumor (BWT) represents 5 - 8% of patients with Wilms' tumor (WT). Despite the improvement of WT survival, still patients with BWT are challenging with a high risk of relapse and renal failure. Purpose: To assess the outcome of pediatric patients with BWT treated at Children's Cancer Hospital Egypt (CCHE) 57357, and to assess the long-term nephrotoxicity among these patients. Methods: This was a retrospective study including all patients with synchronous BWT treated at CCHE 57357 from 2007 until 2020. Records of all patients were reviewed. Patients were followed up until end of December 2024. Results: In 115 eligible patients, median age was 31.5 months (range 3 month - 9 years). Male to female ratio was 1:1.67. Abdominal mass was the most common presentation (69.5%). At the end of the study, 5-year EFS and OS were 69% and 76.7%. Patients with high-risk pathology had the worst prognosis regarding EFS and OS, keeping its significance in uni- and multivariate analyses as the factor with highest hazard ratio (HR = 2.931, 95% CI 1.366 - 6.289 p 0.006). Out of 29 events related to the disease, 21 included local progression/relapse (72.5%), and 8 lung progression/relapse (27.5%). The incidence of ESRD was 6.9% (8 patients). Conclusion: Bilateral Wilms' tumor poses a significant challenge all over the world. Proper timing and type of surgery should be tailored according to each patient. Low-middle income countries face additional challenges related to supportive care for those children who usually present at a very young age with a tangible proportion of them requiring regular hemo dialysis and occasionally renal transplantation.

Indexed as

57357bilateralCCHEchildrenEgyptnephron-sparing surgerysynchronousWilms’ tumor

Identifiers

PMID41234726
PMCPMC12604981

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