Evidence map›Paper›PMID 41234636›Full record

ArticleIranian journal of microbiology2025

Distribution of MBL and serine-β-lactamase-producing pathogens in ventilator-associated pneumonia: insights into MDR and XDR strains.

Zeb Hussain, Asma Naim, Ambreen Fatima, Asad Karim, Fakhur Uddin, Surraya Shams

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In one paragraph

Article in Iranian journal of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Phylogenetic Relationships and Structural Conservation ofInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zeb HussainDepartment of Microbiology, University of Karachi, Karachi, Pakistan.
Asma NaimDepartment of Microbiology, University of Karachi, Karachi, Pakistan.
Ambreen FatimaDepartment of Pathology, Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Asad KarimDepartment of Molecular Medicine, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Fakhur UddinDepartment of Microbiology, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Centre (JPMC), Karachi, Pakistan.
Surraya ShamsDepartment of Clinical Laboratory Sciences, Dow Institute of Medical Technology, Dow University of Health Sciences, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Gram-negative bacteria is a serious ICU challenge. This study determined the prevalence, antimicrobial susceptibility profiles, and phenotypic carbapenemase resistance mechanisms of Gram-negative isolates from VAP patients in two tertiary hospitals in Karachi, Pakistan. Materials and Methods: We included 104 consecutive cases of VAP (July 2021-January 2023). A total of 67 carbapenem-resistant Gram-negative isolates were identified and tested. Antibiotic susceptibility was assessed by disk diffusion and broth micro dilution, according to CLSI and EUCAST guidelines. Modified and enhanced carbapenem inactivation methods (mCIM/eCIM) were used to distinguish metallo-β-lactamase (MBL) and serine carbapenemase production. Results: The mean age was 44.6 ± 18.3 years; 52.2% were male. Early-onset VAP accounted for 37.3% and late-onset for 62.7%. The most frequent pathogens were Conclusion: VAP in our ICUs was dominated by

Indexed as

BacterialCarbapenemsDrug resistanceElizabethkingia meningosepticaRaoultella terrigenaVentilator-associated pneumonia

Identifiers

PMID41234636
PMCPMC12607232

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