Evidence map›Paper›PMID 41234578›Full record

ArticleTranslational lung cancer research2025

Identification of a novel RSPO1-NUMT insertion in a LUAD patient cohort and the challenges and insights into NUMT detection highlighting the importance of reference genomes and population databases.

Ilona Tietzova, Dana Sochorova, Petr Triska, Rebecca C Rancourt, Marek Omelka, Eva Parobkova, Michael Allgäuer, Marc A Schneider, Karsten Senghas, Laura V Klotz and 1 more

Abstract read
In one paragraph

Article in Translational lung cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ilona TietzovaDepartment of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer University Hospital, Prague, Czech Republic.ORCID https://orcid.org/0000-0002-6736-1287
Dana SochorovaDepartment of Surgery, Tomas Bata Hospital Zlin, Zlin, Czech Republic.ORCID https://orcid.org/0000-0003-1925-2892
Petr TriskaIndependent Researcher-Bioinformatician, Vienna, Austria.ORCID https://orcid.org/0000-0002-2663-0006
Rebecca C RancourtInstitute of Clinical Research, Medical School Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0003-2696-7220
Marek OmelkaDepartment of Probability and Mathematical Statistics, Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic.ORCID https://orcid.org/0000-0002-0396-9373
Eva ParobkovaDepartment of Pathology and Molecular Medicine, Third Faculty of Medicine, Charles University and Thomayer University Hospital, Prague, Czech Republic.
Michael AllgäuerInstitute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Marc A SchneiderTranslational Research Unit, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany.ORCID https://orcid.org/0000-0001-8269-3821
Karsten SenghasTranslational Research Unit, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany.
Laura V KlotzTranslational Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.
Marketa TesarovaDepartment of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, and General University Hospital in Prague, Prague, Czech Republic.ORCID https://orcid.org/0000-0002-5141-2289

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nuclear mitochondrial DNA sequences (NUMTs) represent mitochondrial DNA fragments integrated into the nuclear genome with potential clinical significance particularly in the pathology of cancer which have be identified in recent whole-genome sequencing (WGS) studies. Combining NUMT

Indexed as

lung adenocarcinoma (LUAD)lung tumorNuclear mitochondrial DNA sequence (NUMT)R-spondin 1 (RSPO1)WNT pathway

Identifiers

PMID41234578
PMCPMC12605411

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.