ArticleAmerican heart journal plus : cardiology research and practice2025
Evaluation of the predictive value of echocardiography parameters for heart transplant rejection: A tissue Doppler imaging observational study.
Article in American heart journal plus : cardiology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The rate of heart transplantation is increasing worldwide. Due to the limitations of endomyocardial biopsy (EMB), various non-invasive methods have been suggested to assess rejection. Therefore, the aim of this study was to evaluate the predictive value of echocardiographic parameters to determine heart transplant rejection in a sample of Iranian patients. Methods: This was a cross-sectional study on heart transplant patients with available EMB results. All patients underwent echocardiography at the same day of EMB and prior to biopsy. The association between echocardiographic parameters and rejection was assessed using binary logistic regression. Results: A total of 67 patients (50, 74.6 % male and 17, 25.4 % female) with the mean age of 39.20 ± 11.39 years were enrolled in this study. Heart transplant rejection was observed in 22 (32.8 %) patients. There was only a significant difference in mitral inflow peak early diastolic velocity (E) and septal time to peak systolic velocity in ejection phase (septal Ts) between rejection and non-rejection groups. Logistic regression revealed a significant association between rejection and septal Ts ( Conclusion: Septal Ts could be used as a valuable echocardiographic parameter for predicting rejection in heart transplant recipients.
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