Evidence map›Paper›PMID 41234486›Full record

ArticleComputational and structural biotechnology journal2025

Physics-informed AI with chemical master equation dynamics for driver-gene subclone detection and risk labeling.

Komlan Atitey, Caitlin E Hughes, Joseph C Fusco

Abstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Computational and structural biotechnology journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Komlan AtiteyBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences (NIEHS), 111 T W Alexander Dr Rall Building, Research Triangle Park, NC 27709, United States.
Caitlin E HughesDepartment of Pathology, Microbiology and Immunology Monroe Carell Jr Children's Hospital, Vanderbilt 2200 Children's Way, Nashville, TN 37232, United States.
Joseph C FuscoDepartment of Pediatric Surgery Monroe Carell Jr Children's Hospital, Vanderbilt 2200 Children's Way, Nashville, TN 37232, United States.

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
NCI NIH HHS K12 CA090625
6 · The paper itself

Abstract

Subclonal populations shape progression and therapy response but are difficult to resolve in bulk transcriptomes, where rare signals are diluted by dominant clones. Existing methods often treat samples as static mixtures, infer lineages without expression-defined states, or rank genes without specifying when to evaluate, yielding unstable signatures. We propose

Indexed as

Bulk transcriptomicsChemical master equationDriver genesRisk stratificationStochastic gene expressionSubclonal heterogeneity

Identifiers

PMID41234486
PMCPMC12604972

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.