Evidence map›Paper›PMID 41234475›Full record

ArticleAging brain2025

Influence of aging and task-related activation on descending cortical modulation of spinal sensorimotor circuitry.

Alejandro J Lopez, Terrence J Glover, Taylor M Leone, Catherine F Mason, Camille Guzman, Lena H Ting, Michael R Borich, Trisha M Kesar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging brain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alejandro J LopezNeuroscience Graduate Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA, the United States of America.
Terrence J GloverCoulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, the United States of America.
Taylor M LeoneDivision of Physical Therapy, Department of Rehabilitation Medicine, Emory University, Atlanta, GA, the United States of America.
Catherine F MasonNeuroscience Graduate Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA, the United States of America.
Camille GuzmanCoulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, the United States of America.
Lena H TingNeuroscience Graduate Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA, the United States of America.
Michael R BorichNeuroscience Graduate Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA, the United States of America.
Trisha M KesarNeuroscience Graduate Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA, the United States of America.

Funding

Neuromechanical Modeling of Postural Responses:Mechanisms of Balance Impairments in Parkinson's DiseaseR01HD046922 · NICHD · GEORGIA INSTITUTE OF TECHNOLOGY · PI Michael Robert Borich, Lena H Ting · 2004 to 2026
$7.7M
Individual-specific engagement of cortical resources for standing balance control in aging and post strokeR01AG072756 · NIA · EMORY UNIVERSITY · PI Michael Robert Borich, Lena H Ting · 2022 to 2026
$3.0M
NIA NIH HHS R01 AG072756NICHD NIH HHS R01 HD046922
6 · The paper itself

Abstract

The objective of this study was to evaluate the effects of aging on descending modulation of spinal reflexes across different task conditions. In healthy young (YA; age 27 ± 4 years) and older (OA; age 63 ± 10 years) adults, we utilized paired subthreshold transcranial magnetic stimulation (TMS) and peripheral nerve stimulation (PNS) to elicit unconditioned (PNS only) and conditioned (TMS paired with PNS) soleus Hoffmann (H-)reflexes at 3 inter-stimulus intervals (ISIs) (-1.5, +10 ms, +40 ms) and during 3 task conditions - sit rest (SR), sit active (SA), and quiet stance (QS). Our results showed that at the + 40 ms ISI, compared to YA, the OA group showed significant differences in modulation (and reversal from facilitation to inhibition) of soleus H-reflexes during both SA and QS tasks (p < 0.0001). Correlation analysis showed a significant negative relationship between age and the magnitude of H-reflex modulation at the + 40 ms ISI, such that older individuals showed a larger magnitude of H-reflex inhibition. In conclusion, altered task-related modulation of spinal reflexes at the + 40 ms ISI may reflect specific aging-related effects on spinal sensorimotor integration, likely mediated via complex interactions between the influence of polysynaptic slower-conducting descending pathways, sensory afferents, and local spinal circuits, on spinal reflex activity during motor task performance.

Indexed as

AgingHoffmann (H-)reflexSpinal sensorimotor circuitryTask activationTranscranial magnetic stimulation (TMS)

Identifiers

PMID41234475
PMCPMC12607042

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.