ArticleTurkish journal of medical sciences2025
Hesperidin efficacy of epidural fibrosis in a post laminectomy rat model: an experimental study.
Article in Turkish journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Ginsenoside Rg1 mitigates epidural fibrosis after laminectomy in rats: histopathological, TUNEL, and transcriptional evidence.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
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2 authors.
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Abstract
Background/aim: Epidural fibrosis (EF) plays a significant role in the development of failed back surgery syndrome (FBSS). This study evaluates the antifibrotic effect of hesperidin, a citrus-derived bioflavonoid, within a rat laminectomy model. Materials and Methods: Thirty-two female Wistar albino rats were randomized into four groups (n = 8 each). Group 1 received laminectomy alone (control); Group 2 received a gelatin sponge; Groups 3 and 4 intraperitoneally received 50 mg/kg and 100 mg/kg of hesperidin, respectively, for 7 days post-laminectomy. After 6 weeks, epidural tissues were assessed histopathologically, and hydroxyproline levels were measured. Results: Group 4 showed significantly lower EF grades compared with Groups 1 and 2 (p < 0.001), and reduced arachnoid invasion compared with Group 1 (p < 0.05). Group 4 had the lowest hydroxyproline levels (1.19 ± 0.05 μg/mL), followed by Group 3 (1.48 ± 0.16 μg/mL), Group 2 (1.67 ± 0.24 μg/mL), and Group 1 (1.94 ± 0.30 μg/mL) (all p < 0.001). Conclusion: Hesperidin significantly reduced EF and collagen deposition in a dose-dependent manner, demonstrating its potential as a preventive agent for FBSS.
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