ArticleIBRO neuroscience reports2025
Neuroprotective efficacy of methanolic extract of propolis against early life stress-induced oxidative and inflammatory damage: Involvement of the Nrf2-Keap1 signaling pathway.
Article in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Early-life stress (ELS) is a major environmental risk factor for neurobehavioral impairments, including cognitive dysfunction, repetitive behaviors, and social deficits. Propolis, a natural bee product with strong antioxidant and anti-inflammatory properties, may counteract oxidative stress-related disorders. This study examined whether methanolic extract of propolis (MEP) mitigates ELS-induced oxidative and inflammatory damage in a maternal separation (MS) rat model, focusing on the Nrf2-Keap1 pathway. Methods: Male Wistar rats (200-220 g) were allocated to Control, Vehicle, Propolis (200 mg/kg), MS, and MS + Propolis (100 or 200 mg/kg) groups. ELS was induced by separating pups from dams for 3 h/day during postnatal days (P) 1-9. MEP was given orally from P21 to P42. Behavioral tests assessed social interaction, cognition, repetitive, and anxiety-like behaviors. Biochemical analyses measured antioxidant enzymes (SOD, CAT, GRx), glutathione, lipid peroxidation (MDA), and expression of Nrf2, Keap1, IL-6, and TNF-α. Results: MEP (100 and 200 mg/kg) improved social interaction ( Conclusion: MEP alleviates oxidative and inflammatory responses induced by ELS, likely via Nrf2-Keap1 modulation, supporting its potential as a complementary therapy for stress-related neurobehavioral disorders.
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