Evidence map›Paper›PMID 41234358›Full record

ArticleFrontiers in cell and developmental biology2025

Early increased cell proliferation compensates subsequent hypoplasia of the ossicle.

Katsushige Kawasaki, Maiko Kawasaki, Finsa Tisna Sari, Vanessa Utama, Alex Kesuma, Makoto Fukushima, Naoaki Saito, Daisuke Suda, Takehisa Kudo, Akira Fujita and 3 more

Abstract read
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In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Katsushige KawasakiDivision of Oral anatomy, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Maiko KawasakiDivision of Oral anatomy, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Finsa Tisna SariDivision of Oral anatomy, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Vanessa UtamaDivision of Oral anatomy, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Alex KesumaDivision of Oral anatomy, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Makoto FukushimaDivision of Oral anatomy, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Naoaki SaitoDepartment of Tissue Regeneration and Reconstruction, Division of Reconstructive Surgery for Oral and Maxillofacial Region, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Daisuke SudaDepartment of Tissue Regeneration and Reconstruction, Division of Reconstructive Surgery for Oral and Maxillofacial Region, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Takehisa KudoDivision of Oral anatomy, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Akira FujitaFaculty of Dentistry & Graduate School of Medical and Dental Sciences, Division of Orthodontics, Niigata University, Niigata, Japan.
Jun NiharaFaculty of Dentistry & Graduate School of Medical and Dental Sciences, Division of Orthodontics, Niigata University, Niigata, Japan.
Brunella FrancoTelethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.
Atsushi OhazamaDivision of Oral anatomy, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ossicles are essential structures for normal sound conduction from the external environment to the inner ear. Proper formation of the ossicles is required for normal hearing, and ossicular deformities lead to hearing loss. We identified ossicular hypoplasia in mice with mesenchymal conditional deletion of the primary cilia molecule (

Indexed as

cell proliferationHh signalingIFT88neural crest-derived cellsOFD1ossicleprimary cilia

Identifiers

PMID41234358
PMCPMC12605138

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.