Evidence map›Paper›PMID 41234301›Full record

Trial reportOpen forum infectious diseases2025

Virological Success With Long-Acting Cabotegravir and Rilpivirine Despite Historical Rilpivirine Resistance: A Real-World Case Series.

Félix Gutiérrez, Marta Fernández-González, Christian Ledesma, Javier García-Abellán, Leandro López, Melissa Bello-Perez, Sergio Padilla, Federico García, Mar Masiá

Abstract readClinical Trial
In one paragraph

Trial report in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Félix GutiérrezInfectious Diseases Unit, Hospital General Universitario de Elche, Elche, Spain.ORCID https://orcid.org/0000-0002-9485-6867
Marta Fernández-GonzálezInfectious Diseases Unit, Hospital General Universitario de Elche, Elche, Spain.ORCID https://orcid.org/0000-0001-9949-8504
Christian LedesmaInfectious Diseases Unit, Hospital General Universitario de Elche, Elche, Spain.ORCID https://orcid.org/0009-0000-8022-364X
Javier García-AbellánInfectious Diseases Unit, Hospital General Universitario de Elche, Elche, Spain.ORCID https://orcid.org/0000-0002-5217-3726
Leandro LópezInfectious Diseases Unit, Hospital General Universitario de Elche, Elche, Spain.ORCID https://orcid.org/0000-0002-3379-1086
Melissa Bello-PerezInfectious Diseases Unit, Hospital General Universitario de Elche, Elche, Spain.ORCID https://orcid.org/0000-0002-9212-083X
Sergio PadillaInfectious Diseases Unit, Hospital General Universitario de Elche, Elche, Spain.ORCID https://orcid.org/0000-0002-8420-7310
Federico GarcíaCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.ORCID https://orcid.org/0000-0001-7611-781X
Mar MasiáInfectious Diseases Unit, Hospital General Universitario de Elche, Elche, Spain.ORCID https://orcid.org/0000-0001-9878-2458

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a case series of 13 individuals with historical rilpivirine (RPV) resistance-associated mutations, predominantly E138A, long-acting cabotegravir/rilpivirine (CAB/RPV) maintained suppression over a median 24-month follow-up. Twelve were virologically suppressed at switch. No virological failures occurred, supporting cautious CAB/RPV use in selected patients with remote or polymorphic mutations.

Indexed as

E138Along-acting cabotegravir and rilpivirineNNRTI resistancerilpivirine mutationsvirological failure

Identifiers

PMID41234301
PMCPMC12611297

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.