Evidence map›Paper›PMID 41234300›Full record

ArticleOpen forum infectious diseases2025

Clinical Implications of Time to Culture Conversion in

Nakwon Kwak, Youngchan Cho, Jiin Bae, Joong-Yub Kim, Jae-Joon Yim

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nakwon KwakDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.ORCID https://orcid.org/0000-0002-1897-946X
Youngchan ChoDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Jiin BaeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.ORCID https://orcid.org/0009-0001-6631-7583
Joong-Yub KimBiomedical Research Institute, Seoul National University Hospital, Seoul, South Korea.ORCID https://orcid.org/0000-0002-8272-3178
Jae-Joon YimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.ORCID https://orcid.org/0000-0002-9605-0074

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The optimal timing for assessing treatment response in Methods: We retrospectively included MAC-PD patients treated at Seoul National University Hospital between January 2011 and April 2024 who achieved culture conversion within 12 months of treatment initiation. Patients were categorized by time to culture conversion: 0-30, 31-60, 61-90, 91-180, and 181-360 days. Multivariable logistic regression was used to assess the impact of conversion timing on microbiological cure. Results: Among 440 patients, 294 (66.8%) achieved microbiological cure. Compared with those who converted within 30 days, patients who converted at 91-180 days (adjusted odds ratio [aOR], 0.45; 95% CI, 0.24-.87; Conclusions: Failure to achieve culture conversion within 90 days was associated with a significantly lower likelihood of microbiological cure. These findings support the need for timely reassessment and potential modification of treatment strategies in patients who remain culture-positive beyond 90 days.

Indexed as

culture conversioncuremycobacterium avium complex

Identifiers

PMID41234300
PMCPMC12605800

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.