Evidence map›Paper›PMID 41234296›Full record

ArticleBioactive materials2026

A dynamically adaptive wet-adhesive Janus hydrogel patch for sutureless repair of spinal dural defects.

Xin Su, Dezhao Hao, Jiahao Li, Jianchao Xue, Weipeng Chen, Yuan Dong, Xiaomin Tong, Qiushi Bai, Jiansong Zhang, Jia Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xin SuDepartment of Orthopaedics, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Dezhao HaoLaboratory of Bio-inspired Smart Interface Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Jiahao LiDepartment of Orthopaedics, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Jianchao XueDepartment of Orthopaedics, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Weipeng ChenLaboratory of Bio-inspired Smart Interface Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Yuan DongDepartment of Orthopaedics, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Xiaomin TongDepartment of Orthopaedics, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Qiushi BaiDepartment of Orthopaedics, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Jiansong ZhangSchool of Basic Medicine, Shenyang Medical College, Shenyang, 110034, China.
Jia ZhangSchool of Basic Medicine, Shenyang Medical College, Shenyang, 110034, China.
Chi MaDepartment of Orthopaedics, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Jingjing TianBiomedical Engineering Facility of National Infrastructures for Translational Medicine, Institute of Clinical Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Liping WenLaboratory of Bio-inspired Smart Interface Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Yu ZhaoDepartment of Orthopaedics, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective repair of spinal dural defects is essential to prevent cerebrospinal fluid (CSF) leakage and preserve neurological function. However, conventional suture-based methods and clinical bioadhesives often face challenges such as technical complexity, inadequate sealing, and fibrotic adhesion. Here, we present a dynamically adaptive Janus hydrogel patch (DHP) that enables rapid, suture-free sealing while minimizing postoperative adhesion. DHP is fabricated through the self-assembly of viscoelastic polymers into a phase-separated architecture featuring hydrophilic-hydrophobic microdomains, which enables stable and reversible wet adhesion via synergistic interfacial water removal and conformal surface adaptation. The hydrogel exhibits tissue-compliant mechanics, self-healing capability, and stress-relaxation behavior, enabling durable sealing under physiological conditions.

Indexed as

Anti-adhesionDural defectsJanus hydrogelsSuturelessWet adhesion

Identifiers

PMID41234296
PMCPMC12607057

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.