ArticleFrontiers in endocrinology2025
Melatonin modulates the gene expression of WEE1 kinase and clock genes: a crosstalk between the molecular clocks of the placenta?
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The circadian system organizes during 24 hours the temporal variations in biological processes such as the cell cycle, metabolism, and hormone production. This occurs by a transcriptional/translational feedback loop of core clock genes, namely, Objective: We aimed to identify temporally regulated gene expression patterns in the human placenta using bioinformatics analysis of available microarrays in Gene Expression Omnibus (GEO) datasets and to validate selected findings in cultured placental explants. Methods: Temporal microarray data from the GEO were analyzed to identify circadian and cell cycle-related genes. Selected targets were validated Results: We observed rhythmic expression of
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