Evidence map›Paper›PMID 41234188›Full record

SynthesisTransactions of the Royal Society of Tropical Medicine and Hygiene2026

Cerebral malaria: of mice and men.

Chamarika J Weerasekera, Nicholas J White

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Chamarika J WeerasekeraDepartment of Parasitology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.ORCID 0000-0002-7522-0943
Nicholas J WhiteMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.ORCID 0000-0002-1897-1978

Funding

Wellcome Trust 223099/Z/21/Z
6 · The paper itself

Abstract

backgroundCerebral malaria is a major cause of death in endemic areas. An animal model of cerebral malaria has been studied widely in which C57BL/6 mice are infected with the Plasmodium berghei ANKA strain. The histopathology and the response to interventions of human cerebral malaria and the murine model are very different. In 2012, a consensus guideline was published recommending that in order to represent better the clinical setting, interventions in the murine model should be tested together with antimalarial drug treatment and after development of the cerebral syndrome.

methodsA systematic review of publications on human and murine cerebral malaria since 2010 was conducted.

resultsClinical research on human cerebral malaria has declined and still no adjuvant intervention has proved effective. Meanwhile, since 2010, 149 interventions (118 adjuvants) have been evaluated in the mouse model, of which 142 (95%) were reportedly successful. Only 26% of interventions were evaluated after the development of the murine cerebral syndrome and 65% of the adjuvants were tested without a concomitant antimalarial.

conclusionThe predictive value of the murine model in identifying adjuvant therapeutic interventions in human cerebral malaria is very poor.

Indexed as

AntimalarialsDisease Models, AnimalMalaria, CerebralPlasmodium bergheiAnimalsHumansMiceMice, Inbred C57BLAntimalarialsadjuvant treatmentcerebral malariamouse modelsevere malaria

Identifiers

PMID41234188
PMCPMC13017480

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.