ArticleBrain : a journal of neurology2026
Differential selectivity of microglia and astrocytes in HIV-1 gp120-induced synaptic pruning.
Article in Brain : a journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Review
- Environmental enrichment mitigates sevoflurane-induced neurodevelopmental injury via cGAS-STING-dependent microglial modulation.Cell & bioscience · 2026Article
- Nipah virus infects the brain and triggers neuronal and glial damage in a hamster model.Journal of neuroinflammation · 2026Article
- The prefrontal cortex as a target of HIV-1 neurotoxicity: molecular mechanisms of viral protein-mediated neurodegeneration and executive dysfunction.Frontiers in cellular neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Synapse loss is a common neuropathology in the CNS of HIV patients, likely contributing to neurological complications such as neurocognitive disorders and pain. However, the underlying mechanism remains poorly understood. Here, we show microglia- and astrocyte-mediated synaptic pruning of excitatory and inhibitory synapses in the frontal cortex (FC) and spinal dorsal horn (SDH) of HIV-1 gp120 transgenic (gp120Tg) mice compared with the wild-type (WT). Confocal imaging and 3D reconstruction revealed a significant increase of internalized synaptic elements in microglia and astroglia in gp120Tg mice, in a region- and synapse-type-specific manner. Microglia in the FC of gp120Tg mice showed increased pruning activity on the pre-synaptic but not post-synaptic compartment of both excitatory and inhibitory synapses. In contrast, microglia in the SDH of gp120Tg mice had increased pruning activity of both pre- and post-synaptic compartments excitatory and inhibitory compartments in the SDH. However, astrocytes in the gp120 transgenic model increased their pruning activity of both the pre- and post-synaptic compartments of excitatory but not inhibitory synapses in the FC and the SDH. We confirmed synaptic engulfment in viral reservoirs in the brain tissues of human HIV patients. These findings provide important insights into the pathogenic mechanism of synapse loss induced by HIV.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.