Trial reportJournal of the National Cancer Institute2026
Advance care planning impact on caregivers and end-of-life care in advanced cancer.
Trial report in Journal of the National Cancer Institute, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03824158 (Patient-centered and Efficacious Advance Care Planning in Cancer), which is not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Patient-centered and Efficacious Advance Care Planning in Cancer: the PEACe Comparative Effectiveness Trial
Who cites it
1 citing paper in PubMed.
Corrections and comments
- Commented on by
Authors and funding
12 authors.
Funding
Abstract
backgroundAdvance care planning (ACP) may improve outcomes for patients with advanced cancer and their family caregivers, but the optimal approach is not known. This study compared the impact of facilitated versus patient-directed ACP on caregiver psychological symptoms and perceptions of goal-concordant end-of-life (EOL) care.
methodsAdult patients with advanced solid tumors and their caregivers were recruited from 8 oncology clinics in western Pennsylvania. Participants were randomly assigned to complete facilitated ACP with a trained nurse facilitator or patient-directed ACP using written and web-based tools. Caregivers were followed through bereavement and completed surveys assessing depression and anxiety symptoms (Hospital Anxiety and Depression Scale, range 0-21, scores >7 indicative of significant symptoms), post-traumatic stress disorder symptoms (Impacts of Events scale-Revised [IES-R], range 0-88, scores > 24 considered clinically significant), and validated measures of goal-concordant EOL care.
resultsAmong 400 enrolled patients, 272 (68%) had an enrolled caregiver. Caregivers were predominantly female (73%), Caucasian (95%), and were spouses/partners (64%) of the patient with cancer. Among bereaved caregivers (n = 98), those in the facilitated ACP arm reported significantly fewer post-traumatic stress symptoms compared to the patient-directed arm (mean IES-R scores 23.9 vs 31.5, P = .01). Both depression and anxiety symptoms remained similar between arms (depression: 5.34 vs 5.87, P = .50; anxiety: 6.56 vs 6.72, P = .84) and low overall. Caregiver-reported goal-concordant care was higher in the facilitated ACP arm compared to the patient-directed arm (95.8% vs 75.5%, P = .01).
conclusionIn this randomized trial comparing facilitated versus patient-directed ACP, a facilitated approach was associated with lower post-traumatic stress symptoms among bereaved caregivers and higher rates of goal-concordant EOL care. CLINICAL TRIAL REGISTRATION NUMBER: NCT03824158.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.