Evidence map›Paper›PMID 41233856›Full record

ArticleBorderline personality disorder and emotion dysregulation2025

Emotion-focused vs. cognitive interventions of schema therapy for borderline personality disorder: effects on neural emotion regulation networks - study protocol.

Stefan Smesny, Kerstin Langbein, Marina Krylova, Meng Li, Igor Izyurov, Alexander Gussew, Daniel Güllmar, Martin Walter, Gerd Wagner, Jürgen R Reichenbach

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In one paragraph

Article in Borderline personality disorder and emotion dysregulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06367907 (Effects of Emotion-focused vs. Cognitive Schema Therapy Interventions on Emotion Regulation Deficits in Borderline Personality Disorder - Associations Between Clinical Efficacy, Brain Network Function and Local Glutamate/GABA Metabolism), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06367907 naunknown statusnot on this map

Effects of Emotion-focused vs. Cognitive Schema Therapy Interventions on Emotion Regulation Deficits in Borderline Personality Disorder - Associations Between Clinical Efficacy, Brain Network Function and Local Glutamate/GABA Metabolism

TypeinterventionalSponsorJena University HospitalRan2021 to 2025Enrolled120ConditionsPersonality DisordersArmsschema therapy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stefan SmesnyDepartment of Psychiatry, Jena University Hospital, Philosophenweg 3, Jena, 07743, Germany. stefan.smesny@med.uni-jena.de.
Kerstin LangbeinDepartment of Psychiatry, Jena University Hospital, Philosophenweg 3, Jena, 07743, Germany.
Marina KrylovaDepartment of Psychiatry, Jena University Hospital, Philosophenweg 3, Jena, 07743, Germany.
Meng LiDepartment of Psychiatry, Jena University Hospital, Philosophenweg 3, Jena, 07743, Germany.
Igor IzyurovDepartment of Psychiatry, Jena University Hospital, Philosophenweg 3, Jena, 07743, Germany.
Alexander GussewDepartment of Medical Physics, University Hospital Halle (Saale), Halle (Saale), Germany.
Daniel GüllmarInstitute of Diagnostic and Interventional Radiology, Medical Physics Group, Jena University Hospital, Philosophenweg 3, Jena, 07743, Germany.
Martin WalterDepartment of Psychiatry, Jena University Hospital, Philosophenweg 3, Jena, 07743, Germany.
Gerd WagnerDepartment of Psychiatry, Jena University Hospital, Philosophenweg 3, Jena, 07743, Germany.
Jürgen R ReichenbachInstitute of Diagnostic and Interventional Radiology, Medical Physics Group, Jena University Hospital, Philosophenweg 3, Jena, 07743, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile the effects of psychotherapy methods are being intensively researched, little is known about the clinical and neurobiological effects of specific psychotherapeutic interventions. This study examines the effects of experiential emotion-focused and cognitive interventions in schema therapy on emotion regulation in borderline personality disorder.

methodsIn a randomized, single-blinded, parallel group design, clinical effects and effects on resting-state functional connectivity in neural emotion regulation networks and neurotransmitter metabolism (Glx/GABA) in key regions of these networks are compared. The 9-week treatment protocol includes emotion-focused interventions such as chair dialogues, imagery rescripting, or mode role-playing in the test condition; these interventions are omitted in the active control condition (dismantling design). Resting-state functional MR imaging (rsfMRI) and MEGA-sLASER 1 H MR spectroscopy in the pregenual cingulate cortex (pgACC), anteromedial cingulate cortex (aMCC), and dorsolateral prefrontal cortex (DLPFC) are performed before and after the therapy interval and 6 months after the end of therapy and compared with the neurobiological parameters of healthy control subjects. The clinical effects are recorded using a comprehensive test battery and specified using the Reliable Change Index (RCI). Clinical and biological data are examined using mixed model analysis both longitudinally and in terms of their interactions. DISCUSSION: The aim is to show that different psychotherapeutic interventions have different effects on deficits in emotion regulation associated with specific effects on neural emotion regulation networks. This would contribute to a better understanding of the neurobiological effects and mechanisms underlying psychotherapeutic core interventions and to their more targeted use in BPD and other related disorders in the future.

trial registrationClinicalTrials.gov Identifier: NCT06367907, Retrospectively registered, April 2024.

Indexed as

Behavioral therapyBorderline personality disorderFunctional brain connectivityGABAGlutamateProton MR spectroscopyResting-state functional MR imagingSchema therapy

Identifiers

PMID41233856
PMCPMC12616957

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.