ArticleBMC medical imaging2025
Cerebral small vessel disease score associated with brain hypoperfusion predicts cognitive decline: a longitudinal study.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Evolution of cortical cerebral microinfarcts on 3T MRI: risk factors and clinical relevance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Imaging research, diagnosis, and treatment advances of post-stroke cognitive impairment.Frontiers in neuroimaging · 2026Review
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Authors and funding
10 authors.
Funding
Abstract
backgroundThis study aimed to investigate the association between cerebral small vessel disease (CSVD) score and cerebral blood flow (CBF) at baseline in cognitively intact older adults and to explore whether the total CSVD burden score serves as an imaging marker that can predict cognitive impairment in aging populations.
methodsMR images acquired from 509 participants with normal cognition were analyzed to evaluate the association between the total CSVD burden score and CBF. Structural scans, pseudo-continuous arterial spin labelling (pCASL) for CBF quantification, and 3D T1-weighted sequences were obtained. CSVD burden scores were rated using a validated 5-point scale by assessing white matter hyperintensity, lacunes, perivascular spaces, and microbleeds. Participants underwent structured cognitive assessments via telephone at a mean follow-up of 7.6 ± 0.1 years post-baseline. Differences in CBF between the CSVD burden groups were compared using univariate linear models, and logistic regression analysis was conducted to estimate the risk of longitudinal cognitive impairment. The predictive model was evaluated using the receiver operating characteristic (ROC) curve analysis.
resultsSevere CSVD scores (> 2) were significantly associated with decreased CBF in many cortical regions (P
conclusionSevere CSVD score, which is associated with cortical hypoperfusion, was found to be an effective imaging marker for predicting longitudinal cognitive decline. Thus, CSVD scoring may be considered a clinically accessible tool for risk stratification and individualized health monitoring in aging populations.
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