ArticleBMC pediatrics2025
Application of the PECARN prediction rule for febrile infants up to 90 days of age: a multi-center study.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
backgroundPrediction rules using biomarkers to stratify young febrile infants at low risk for bacterial infections have been developed over the last decade in North America and Europe. The aim of this study was to validate the Pediatric Emergency Care Applied Research Network (PECARN) prediction rule for febrile infants 90 days of age and younger presenting to the emergency department (ED) in tertiary care centers in Saudi Arabia.
methodsA multi-center retrospective study was conducted on febrile infants who presented to the ED at 3 Saudi hospitals between January 2018 and June 2021. Patients were included if they were full-term, 0-90 days of age, had documented fever, and procalcitonin (PCT) performed.
resultsA total of 327 patients met inclusion criteria. Fifty-three patients (16.2%) had serious bacterial infections (SBIs), 33 with urinary tract infection (UTI) alone and 20 with invasive bacterial infections (IBIs) (bacteremia and/or bacterial meningitis). The mean absolute neutrophil count was 6.6 × 10
conclusionsSBIs are common in our population, and the PECARN prediction rule performed well in classifying febrile infants at low risk for SBIs. The prediction rule was very accurate in ruling out IBIs, with no misclassified cases in infants 3 weeks of age and older. Our study helps validate the applicability of the PECARN prediction rule in our setting.
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