ArticleBMC infectious diseases2025
Clinical features, microbiological characteristics, and treatment outcomes of fungal keratitis in a tertiary referral hospital in Eastern China.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundFungal keratitis (FK) is a serious corneal disease that was considered as the main cause of vision loss in developing countries. Early diagnosis and timely treatment of FK can significantly strengthen the curative effect and decrease the risk of the blindness. The fungal spectrum varies and is closely associated with climate and geographic location. The clinical characteristics of FK in eastern China are limited. We explored the risk factors, fungal species, characteristics of in vivo confocal microscopy (IVCM), and treatment of FK in a tertiary referral hospital in eastern China.
methodsThis retrospective study encompassed a thorough analysis of clinical data, IVCM images, and fungal cultures in FK between January 2021 and May 2024. The clinical profiles, microbial characteristics, and therapeutic outcomes of these patients were meticulously analyzed.
resultsA total of 174 patients were diagnosed with FK. Seven fungal species were identified in 104 culture-positive cases. Fusarium was the most common species (49.04%), followed by Alternaria (23.08%) and Aspergillus (15.38%). 166 (95.4%) patients showed evidence of mycelia or spores in IVCM images. Diverse fungal strains typically showed varied culture characteristics and IVCM expressions. 42 (24.14%) patients were successfully treated with topical medicine alone, and 132 (75.86%) patients needed additional surgical therapies, including intrastromal injections of voriconazole (38.51%), conjunctival pedicle flap surgery (8.05%), lamellar keratoplasty (22.41%), penetrating keratoplasty (4.02%), and enucleation (2.87%). Visual acuity improved in 104 patients (59.77%), but remained unchanged in 36 (20.69%) patients and decreased in 34 patients (19.54%) following active treatment. CONCLUSIONS FUSARIUM: was the most frequently isolated species, followed by Alternaria and Aspergillus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.